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Serious side effects may include mental health problems and an increased risk of infection. Methylprednisolone was approved for medical use in However, glucocorticoids have a wide range of effects, including changes to metabolism and immune responses. The list of medical conditions for which methylprednisolone is prescribed is rather long and is similar to other corticosteroids such as prednisolone. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. It is used both in the treatment of acute periods and long-term management of autoimmune diseases, most notably systemic lupus erythematosus.

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Depo-Medrol 20 is recognized for its anti-inflammatory effects. An injectable steroid, it is helpful for overwhelming infections, allergic reactions, and pain caused by diseases such as arthritis.

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