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The goal of antihypertensive therapy is to provide good blood pressure BP control without eliciting adverse effects. This study compared the risk-benefit profile of the angiotensin II receptor blocker valsartan with that of the angiotensin-converting enzyme inhibitor lisinopril in patients with mild to severe hypertension. Patients were randomized to receive once-daily, oral, self-administered treatment with valsartan mg capsules or lisinopril mg capsules under double-blind conditions for 4 weeks. Responders continued monotherapy, whereas nonresponders had hydrochlorothiazide The 2 primary variables used to assess the equivalence of therapeutic efficacy of the 2 regimens were sitting SBP and sitting DBP, which were measured at weeks 0 baseline, 4, 8, and A total of patients were enrolled men, women; mean age,

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Lisinopril is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat heart failure and to improve survival after a heart attack.

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