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Topiramate Topamax is an antiepileptic drug recently approved by the U. Its exact mechanism of action is uncertain, but it is known to affect neuronal hyperexcitability, 1 which is one probable factor in the development of migraine. Clinical trials and experience with topiramate have not identified serious safety concerns. In three large randomized controlled trials 2 — 4 in which collectively almost 1, patients received topiramate,10 patients reported renal calculi, and for three of these patients this resulted in discontinuation of the medication. Topiramate is FDA pregnancy category C, and is excreted in breast milk.

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What is topiramate, and how does it work mechanism of action? Topiramate is an oral drug that is used to prevent the seizures of epilepsy.

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The Drug is prescribed to treat epileptic syndrome, migraine, tonic-clonic seizures seizures affecting the whole brain and Lennox-Gastaut syndrome LGS. The drug is used to treat epilepsy at initial stage, migraine and relieve seizures.

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